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PCA-2 (Purkinje Cell Antibody 2) Line Assay and Purkinje Line Assay AVAILABLE ON REQUEST PCA-2 Line Assay Line Assay for the detection of paraneoplastic PCA-2 autoantibodies to the Mikrotubulin-associated protein MAP1B Purkinje Line Assay Line Assay for the detection of paraneoplastic PCA-2 autoantibodies anti-Yo (PCA-1), anti- MAP1B (PCA-2), anti-Tr (DNER) and anti-Protein Kinase C ɣ (PKCɣ) PCA-2 autoantibodies are known for almost two decades. These autoantibodies bind to a 280 kDa protein in dendrites and somata of Purkinje cells showing a typical staining pattern. Clinical symptoms comprise cerebellar ataxia, brainstem, and limbic encephalitis, autonomic or motor neuropathy and Lambert-Eaton myasthenia syndrome (LEMS). As underlying antigen MAP1B, a member of the microtubule-associated protein family (MAP) has been identified. Small cell lung cancers (SCLC) are the most common associated tumours. Autoantibodies to MAP1B often co-exist with autoantibodies to GAD 65, HuD, CV2 (CRMP5), Amphiphysin and SOX1 and also with autoantibodies to surface proteins like VGKC and VGCC (Voltage Gated Potassium resp. Calcium Channels).
ravo Diagnostika, Oltmannsstr. 5, D-79100 Freiburg
phone +49 761 40 74 88, fax +49 761 40 74 77, email |
